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During ultrasound evaluation of the bladder, we found it unnecessary to perform urethral catheterization beforehand.

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Chemical burn is then introduced to the bladder mucosa using intravesical silver nitrate solution to disrupt the bladder glycosaminoglycan layer and allows cells to attach.

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Urine seen within the catheter confirms its location within the bladder lumen.

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In our experience, catheterization of athymic nude mice is more difficult than in C57 mice.

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We present a novel method for treating bladder cancer with intravesically delivered small activating RNA saRNA in an orthotopic xenograft mouse bladder tumor model.



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